Senior Director/Vice President, Preclinical Pharmacology
Full Time • Gaithersburg
Benefits:
- 401(k) matching
- Bonus based on performance
- Dental insurance
- Free food & snacks
- Health insurance
- Paid time off
Position Overview
Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as Senior Director or Vice President, Preclinical Pharmacology.
This SD/VP will be responsible for integrating in vivo pharmacology, PK/PD, and toxicology into the company's R&D strategy, with a strong foundation in cardiovascular and metabolic disease biology to inform nonclinical development plans and translational strategy. This role guides programs from late research through IND/CTA submissions, ensuring alignment with regulatory and scientific standards, and will have a lasting impact on the company's scientific direction and future success.
Key Responsibilities
• Preclinical Pharmacology Oversight: Leverage disease biology knowledge to design, manage, and interpret pharmacology and PK/PD studies, and guide and oversee toxicology studies (GLP/non-GLP), to enable development candidate nomination and IND application. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages.
• Cross-Functional Integration: Lead cross-functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans.
• Strategic Program Leadership: Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategies across the portfolio and drive new discovery initiatives grounded in scientific rigor and corporate strategy.
Required Qualifications
• PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline
• 10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical drug discovery and/or pharmacology
• Demonstrated ability as program lead to advance programs from lead optimization to IND approval; preference for experience with complex biologics, such as antibodies (multispecific, antibody-protein fusions), and/or antibody conjugates (antibody-drug conjugates with small molecule payloads such as cytotoxic agents, toxins or others, antibody-oligonucleotide conjugates such as antisense oligos, siRNAs).
• Deep expertise in cardiovascular and/or metabolic disease biology, with working experience designing and interpreting disease-relevant in vivo models.
• Solid working knowledge in bioanalysis, PK/PD, and DMPK. Sufficient understanding of toxicology principles to provide scientific oversight of GLP and non-GLP toxicology studies conducted at CROs.
• Experience delivering high-quality preclinical/nonclinical data packages for development candidate selection and IND application. Familiarity with FDA/EMA expectations for nonclinical data packages supporting biologics development.
• Experience across oncology and CVM therapeutic areas is a strong plus.
Skills & Competencies
• Strong strategic thinking and scientific judgment with excellent problem-solving capabilities
• Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences
• Strong interpersonal skills with the ability to motivate, influence, and lead cross-functional teams in a matrixed environment
• Demonstrated ability to work collaboratively and influence at all levels of the organization
• Independent, self-motivated leader with the ability to work in a fast-paced, team-based drug discovery and development environment
About Salubris Biotherapeutics
Salubris Biotherapeutics, Inc. (or SalubrisBio) is a clinical-stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics for the treatment of cancer, cardiovascular, and metabolic diseases. We are advancing a robust complex biologics pipeline including antibody-drug-conjugate and antibody-fusion programs, with a commitment to transforming patient outcomes through scientific excellence and innovation. We offer a competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits. SalubrisBio is an equal opportunity employer committed to diversity and inclusion in the workplace.
Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as Senior Director or Vice President, Preclinical Pharmacology.
This SD/VP will be responsible for integrating in vivo pharmacology, PK/PD, and toxicology into the company's R&D strategy, with a strong foundation in cardiovascular and metabolic disease biology to inform nonclinical development plans and translational strategy. This role guides programs from late research through IND/CTA submissions, ensuring alignment with regulatory and scientific standards, and will have a lasting impact on the company's scientific direction and future success.
Key Responsibilities
• Preclinical Pharmacology Oversight: Leverage disease biology knowledge to design, manage, and interpret pharmacology and PK/PD studies, and guide and oversee toxicology studies (GLP/non-GLP), to enable development candidate nomination and IND application. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages.
• Cross-Functional Integration: Lead cross-functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans.
• Strategic Program Leadership: Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategies across the portfolio and drive new discovery initiatives grounded in scientific rigor and corporate strategy.
Required Qualifications
• PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline
• 10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical drug discovery and/or pharmacology
• Demonstrated ability as program lead to advance programs from lead optimization to IND approval; preference for experience with complex biologics, such as antibodies (multispecific, antibody-protein fusions), and/or antibody conjugates (antibody-drug conjugates with small molecule payloads such as cytotoxic agents, toxins or others, antibody-oligonucleotide conjugates such as antisense oligos, siRNAs).
• Deep expertise in cardiovascular and/or metabolic disease biology, with working experience designing and interpreting disease-relevant in vivo models.
• Solid working knowledge in bioanalysis, PK/PD, and DMPK. Sufficient understanding of toxicology principles to provide scientific oversight of GLP and non-GLP toxicology studies conducted at CROs.
• Experience delivering high-quality preclinical/nonclinical data packages for development candidate selection and IND application. Familiarity with FDA/EMA expectations for nonclinical data packages supporting biologics development.
• Experience across oncology and CVM therapeutic areas is a strong plus.
Skills & Competencies
• Strong strategic thinking and scientific judgment with excellent problem-solving capabilities
• Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences
• Strong interpersonal skills with the ability to motivate, influence, and lead cross-functional teams in a matrixed environment
• Demonstrated ability to work collaboratively and influence at all levels of the organization
• Independent, self-motivated leader with the ability to work in a fast-paced, team-based drug discovery and development environment
About Salubris Biotherapeutics
Salubris Biotherapeutics, Inc. (or SalubrisBio) is a clinical-stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics for the treatment of cancer, cardiovascular, and metabolic diseases. We are advancing a robust complex biologics pipeline including antibody-drug-conjugate and antibody-fusion programs, with a commitment to transforming patient outcomes through scientific excellence and innovation. We offer a competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits. SalubrisBio is an equal opportunity employer committed to diversity and inclusion in the workplace.
Compensation: $200,000.00 - $300,000.00 per year
Mission
At SalubrisBio, our mission is to develop first-in-class biologics that improve the health and quality of life of people living with complicated diseases.
We have the passion, commitment, and expertise needed to drive our assets through all phases of clinical development to deliver novel biologic therapies to patients. We believe we can achieve our ambitions by embracing challenges and valuing teamwork.
SalubrisBio is the first company in the world to bring a bispecific antibody into clinical trials in a cardiovascular indication. We endeavor to make this the first of many global innovation achievements.
Join Our Team
Our Values
At SalubrisBio we have passion, commitment, and enthusiasm for innovative drug discovery and development. We embrace challenges and value teamwork to solve problems and achieve our ambitions.
Positions
Salubris Biotherapeutics, Inc. (or SalubrisBio) is a science-driven biotechnology company dedicated to the discovery and global development of novel complex biologics for the treatment of cancer and cardiovascular diseases. We strive to develop novel therapeutic molecules which provide clinically meaningful improvements in disease burden and quality of life to patients with significant medical needs. SalubrisBio is seeking highly motivated individuals with exceptional abilities to join our antibody drug research and development programs.
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